Rutin Inhibits Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation by Inducing Autophagy and Modulating PI3K/ATK Signaling

Rutin Inhibits Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation by Inducing Autophagy and Modulating PI3K/ATK Signaling

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Atherosclerosis (AS) is one of the leading causes of death among the elderly, and is primarily caused by foam cell grandpas best generation and macrophage inflammation.Rutin is an anti-inflammatory, anti-oxidant, anti-allergic, and antiviral flavonoid molecule, known to have anti-atherosclerotic and autophagy-inducing properties, but its biological mechanism remains poorly understood.In this study, we uncovered that rutin could suppress the generation of inflammatory factors and reactive oxygen species (ROS) in ox-LDL-induced M2 macrophages and enhance their polarization.

Moreover, rutin could decrease foam cell production, as shown by oil red O staining.In addition, rutin could increase the number of autophagosomes and the LC3II/I ratio, emtek 2113 while lowering p62 expression.Furthermore, rutin could significantly inhibit the PI3K/ATK signaling pathway.

In summary, rutin inhibits ox-LDL-mediated macrophage inflammation and foam cell formation by inducing autophagy and modulating PI3K/ATK signaling, showing potential in treating atherosclerosis.